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 Diseases Related to Bioaerosols

Contagious Diseases: Many Viral and Bacterial Diseases

Infection
Organisms must be viable.
Transmission Mode
Human to human.
Route of Infection
Through air or by contact.
Agents
Viruses: cannot reproduce without hosts, may survive on surfaces including ventilation or filtration.  Bacteria (e.g., tuberculosis): generally not found in building substrates.
Risk Factors
Genetic factors, lack of immunity, dose, virulence of agents, environmental factors: Immune deficiency; medications, substances abuse, etc.
Evaluation
Diagnosis, epidemiology; air/source sampling is ineffective.
Control
Avoid contact.
Infections from Environmental Sources: Many Bacterial & Fungal Diseases
Infection
Organisms must be viable; may also cause allergic/toxic response.
Transmission Mode
Environmental reservoirs; some such as chlamydia and rickettsia are assoc. with vector carriers such as rodents or other mammals.
Route of Exposure
Through air or by contact.
Agents
Bacteria: Legionella (Legionnaire's disease and Pontiac Fever); flavobacteria, etc., Fungi: histoplasma, blastomyces, coccidioidomyces, Cryptococcus, Aspergillius, etc.
Risk Factors
Genetic factors, lack of immunity, dose, virulence of agents, environmental factors. Immune deficiency; medications, substance abuse, etc.
Evaluation
Diagnosis, epidemiology; site observation, source sampling; air sampling may be useful for Aspergillius and Pseudomonas, but difficult for Legionella.
Control
Remove sources.
Hypersensitivity: Asthma & Hay Fever
Immune Response
Diseases; agents of exposure need not be alive.
Transmission Mode
Environmental reservoirs.
Route of Exposure
Inhalation.
Agents
Fungi (mostly spores), pollens, arthropods (mites, roaches) mammals (cat and dog danders), etc.
Risk Factors
Genetic factors, sensitization, antigenicity.

 

Evaluation
Diagnosis, site observation source sampling of reservoirs, air sampling.
Control
Remove sources, avoid allergens.
Hypersensitivity: Hypersensitivity Pneumontis
Immune Response
Diseases; agents of exposure need not be alive.
Transmission Mode
Environmental reservoirs.
Route of Exposure
Inhalation.
Agents
Bacteria, actinomyces, fungi (mostly spores), protozoa, proteins, biological organic dust.
Risk Factors
Host risk unknown, prolonged and high levels of exposure, adjuvents, antigenicity.
Evaluation
Diagnosis, source sampling of reservoirs, air sampling.
Control
Remove sources, avoid allergens.

 Toxicoses: Acute Toxicity, Immune Suppression, Cancer & Human Fever

Direct Cellular Effect
Toxins or carcinogens of biological origin; exposure units need not be alive, and may linger, depending on chemical stability; cancer is rare.
Transmission Mode
From environmental reservoirs, either assoc. with organisms or discharge by organisms.
Agents
Bacteria toxins: endotoxins and exotoxins.  Fungal toxins, mycotoxins, such as alfatoxins.
Risk Factors
Human response is constant; toxicity, dose, immune suppressors.
Evaluation
Diagnosis, site observation source sampling of organisms, air sampling to verify exposure
Control
Remove sources.
Extracted from Suggested Guidelines for Remediation of Damage from Sewage Backflow into Buildings
An  Environmental Protection Agency (EPA) Working Document

Michael A. Berry, Ph.D., Jeff Bishop, Claude Blackburn, Eugene C. Cole, Dr., Ph.D., William G. Ewald,
Terry Smith, Nathan Suazo, and Steve Swan

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